Neomycin Sulphate
Neomycin Sulphate
CAS: 1405-10-3
Molecular Formula: C23H48N6O17S
Neomycin Sulphate - Names and Identifiers
| Name | Neomycin Sulphate |
| Synonyms | neomix mycigient neobiotic neofracin newfrancef neo-mantlecreme Nystatin sulfate neomycinesulfate Neomycin Sulfate Neomycin Sulphate mycifradin sulfate FRADIOMYCIN SULFATE NEOMYCIN SULPHATE pure (2S,3S,4S,5S,6S)-5-amino-2-(aminomethyl)-6-[(1S,2S,3S,4R,6R)-4,6-diamino-2-[(2R,3S,4R,5S)-4-[(2S,3S,4S,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol,sulfuric acid |
| CAS | 1405-10-3 |
| EINECS | 215-773-1 |
| InChI | InChI=1/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6-,7+,8-,9+,10+,11+,12+,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23-;/m1./s1 |
| InChIKey | OIXVKQDWLFHVGR-VTSVPHRWSA-N |
Neomycin Sulphate - Physico-chemical Properties
| Molecular Formula | C23H48N6O17S |
| Molar Mass | 712.72 |
| Melting Point | >187°C (dec.) |
| Boling Point | 1046.1°C at 760 mmHg |
| Specific Rotation(α) | D20 +54° (c = 2 in H2O) |
| Flash Point | 56℃ |
| Water Solubility | Soluble in water |
| Solubility | H2O: 50mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White to light yellow powder |
| Color | white to slightly yellow |
| Merck | 14,6454 |
| PH | 5.0-7.5 (50g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Sensitive to light and humidity |
| Refractive Index | 56 ° (C=10, H2O) |
| MDL | MFCD00077833 |
| Use | For broad-spectrum antibiotics, Staphylococcus aureus, diphtheria and Bacillus anthracis good |
| In vitro study | The Neomycin interacts preferentially with the ribozyme-substrate complex, and this interaction leads to a reduction in the rate of cleavage, by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step. Neomycin causes a conformational change in the structure of the transactivation Region (TAR), which can be detected by circular dichroism spectroscopy. Neomycin acts as a non-competitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (Koff) for the dissociation of RNA and peptides. Neomycin is the most potent of the aminoglycosides (groove binders) used to stabilize the triple helix of DNA. Neomycin stabilizes TAT, as well as the mixed-base DNA triple helix, better than the known DNA minor groove binders (which normally disrupt the triple helix) and polyamines. Neomycin stabilizes the TAT triple helix better, but can also stabilize the CGC() triple helix. Neomycin concentration-and voltage-dependent induction of partial inhibition of channels in the cytosolic and luminal surfaces. Neomycin has a greater affinity for the lumen than for the cytoplasm: the dissociation constants at zero voltage (Kb(0)) are 210.2 nM and 589.7 nM, respectively. Neomycin also showed voltage-dependent remission of inhibition at potentials greater than 60 mV. |
Neomycin Sulphate - Risk and Safety
| Risk Codes | R42/43 - May cause sensitization by inhalation and skin contact. R22 - Harmful if swallowed |
| Safety Description | S23 - Do not breathe vapour. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S22 - Do not breathe dust. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | QP4375000 |
| FLUKA BRAND F CODES | 8 |
| TSCA | Yes |
| HS Code | 29419000 |
| Toxicity | LD50 oral in mouse: > 8gm |
Neomycin Sulphate - Upstream Downstream Industry
| Raw Materials | Ammonium hydroxide Ammonium sulfate Sodium bisulfate |
Neomycin Sulphate - Reference
| Reference Show more | 1. Li Zhongling, Zhang Hongyan, Fu Bo, et al. Study on fermentation conditions of butyricum MYS66 [J]. China Brewing, 2018, 037(002):75-79. 2. Wu Qin, Xu Ziyang, Liu Liping, et al. Role of intestinal flora in stress-induced hypertension in rats [J]. Biotechnology Bulletin, 2020, v.36;No.331(02):88-95. 3. Zheng Jie, Xu Yifan, Chen Yanyan, Zhou Yijing, Zhang Yuheng, Yu Xuerui, Hong Min. Ganmai Dazao Decoction Combined with Fluoxetine to Improve Depression Symptoms in Chronic Stress Mice by Regulating Intestinal Flora [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2020,36(05):667-674. 4. Ming Lu, Chenyang Cao, Feng Wang, Guocong Liu,A polyethyleneimine reduced graphene oxide/gold nanocubes based electrochemical aptasensor for chloramphenicol detection using single-stranded DNA-binding protein,Materials & Design,Volume 199,2021,109409, 5. Zhang, Fangxing, et al. "The Endogenous Alterations of the Gut Microbiota and Feces Metabolites Alleviate Oxidative Damage in the Brain of LanCL1 Knockout Mice." Frontiers in microbiology 11 (2020): 2126.https://doi.org/10.3389/fmicb.2020.557342 6. [IF = 5.833] He Baoshan et al. "Voltammetric kanamycin aptasensor based on the use of thionine incorporated into Au @ Pt core-shell nanoparticles." Microchim Acta. 2019 Feb;186(2):1-8 7. [IF = 7.991] Ming Lu et al. "A polyethyleneimine reduced graphene oxide/gold nanocubes based electrochemical aptasensor for chloramphenicol detection using single-stranded DNA-binding protein." Mater Design.2021 Feb;199:109409 8. [IF = 4.235] Zhang Fangxing et al. "The Endogenous Alterations of the Gut Microbiota and Feces Metabolites Alleviate Oxidative Damage in the Brain of LanCL1 Knockout Mice." Front Microbiol. 2020 Oct;0:2126 9. [IF = 2.082] Qin Guo et al. "Synergistic inhibition effects of tea polyphenols as adjuvant of oxytetracycline on Vibrio parahaemolyticus and enhancement of Vibriosis resistance of Exopalaemon carinicauda." Aquac Res. 2021 Aug;52(8):3900-3910 10. [IF = 6.475] Chunjun Li et al. "Colon and gut microbiota greatly affect the absorption and utilization of astaxanthin derived from Haematococcus pluvialis." FOOD RESEARCH INTERNATIONAL. 2022 Jun;156:111324 |
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Raw Materials for Neomycin Sulphate